320-susy is a project mainly written in ..., it's free.
combining Andy Clarke's '320-and-up' boilerplate with Susy's responsive grids.
320 and up is a 'tiny screen first' boilerplate extension by Andy Clarke.
Susy is a flexible grid-building tool by Eric Meyer, built in Compass/Sass.
This is an example of how one might use them together, to build different grids for different devices on one site.