Growlnotify is a project mainly written in Perl, it's free.
Growl notifications for irssi+screen over SSH
It's a pair of pretty simple perl scripts to pop up Growl notifications when someone hilights or queries you in your irssi session which you are connected to via SSH.
The irssi plugin is currently set up so that it reacts to query windows changing to hilighted state (so you get a notification when someone sends you a message, but not again when you already have the query window open) as well as hilights (so you get a notification when someone mentions your name).
It then connects to a local port tunnelled through SSH to your local machine where the second perl script listens and sends a UDP packet to Growl.
Yes, but none of them worked for me.
iTerm2 supports Growl notifications via terminal escape sequences, but they don't work through GNU screen because screen filters out non-standard escape sequences.
Some people use a second SSH connection to tail -f a notification file written to by fnotify.pl. Some people tunnel their local SSH port through the SSH connection to the irssi host, which then connects back to the local host via SSH for every notification. That just seemed excessive and way too complicated.
Simply tunnelling the Growl port via SSH isn't possible out of the box because it uses UDP (in theory, it should be possible to send notifications via Growl's TCP port too, but I couldn't get that to work). There is a new protocol called GNTP that uses TCP, but it's only supported by Growl 1.3 which has gotten a lot of bad reviews so I'm still using 1.2.2.
My solution is as simple as it gets without requiring Growl 1.3.